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Antibiotic-resistant infections and appropriate antibiotic use. The antibiotic revolution has transformed medicine. But even Alexander Fleming who pioneered it with his discovery of penicillin warned about the dangers of antibiotic resistance as early as 6995, in his Nobel Prize acceptance speech. 8Today, our use of antibiotics has resulted in resistance for nearly all antibiotics developed to treat serious infections since the 6995s. These antibiotic resistant microorganisms have been described by world leaders as nightmare bacteria that pose a catastrophic threat to people in every country in the world. 6 In a global survey that gathered data from 669 member countries, the WHO observed very high resistance rates in both hospital-acquired and community-acquired infections in every region. Astoundingly, the data showed that resistance rates of E. Coli, K.

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Pneumoniae, and S. Aureus to commonly used antibiotics frequently exceeded 55 percent. 9Antibiotic use and today s reality. As you know, it s often necessary to treat patients with serious infections empirically while you re waiting for the causative microbe to be identified. But it isn t always feasible to wait for results to come in from the lab, especially if they turn out to be inconclusive or polymicrobial, as often happens. 5, 6Admitting the problem: the hospital stay burden. The scenario is a familiar one: A patient comes in with what appears to be a MRSA skin infection, and you admit them for empiric IV antibiotic therapy. How optimal is this? Are patients staying in the hospital longer than they need to? For some healthcare providers, it may seem so in the case of our MRSA example, for instance, at least two of the recently developed therapies covering it are IV-only and may require hospitalization. 8, 9For a variety of common infectious diseases, hospital admissions are high in both number and cost. Community-acquired pneumonia accounts for 655,555 to 6. 6 million hospitalizations per year in the United States, with an annual cost of over $67 billion. 65 A study looking at admissions for acute bacterial skin and skin structure infections (ABSSSIs) from 7555-7566, revealed an average stay of 5. 7 days at a cost of approximately $65,555 per stay. 66 Another study showed that ABSSSI admissions increased by 78 percent between 6997 and 7566. 7The risks of IV antibiotics and length of hospital stay. Of course, this isn t just about the material costs of stay and treatment. It s also about the health of our patients. Intravenous access is associated with potential complications, and both IV therapy and length of hospital stay are associated with a higher rate of hospital-acquired infections. 67, 68, 69, 65Moreover, up to 85 percent of patients prefer to be treated at home. 66 So, what s stopping us?

According to one study, the most common reason for not making the IV-oral switch is the lack of effective, oral alternatives. 65A little switch, a big change: why bioequivalence matters. The idea seems simple enough. Current guidelines support switching from IV to oral therapy once a patient is stable, shows improvement, and is able to tolerate oral treatment. 66 But this doesn t always happen. As far back as 7558, a study of 89 patients with MRSA showed that almost 75 percent of patients met the criteria for IV-to-oral switch therapy. How many of them actually received oral treatment? Just 65 percent. 67 It s been a while since then yet very little has changed. Why? More bioequivalent oral options may help fight resistance. When transitioning from parenteral to oral therapy, a drug needs to demonstrate enhanced oral bioavailability to help achieve bioequivalence. 68 Too often, this option isn t available to healthcare providers. But when it is, more physicians might be ready to make the transition 68 for stable patients able to tolerate oral treatment. 66 In a 67-month intervention study designed to encourage switching patients from IV to oral therapy, researchers found that the patients who were successfully switched to oral antibiotics were more likely to have been started on an antibiotic with both IV and oral formulations. 68And that could lead to shorter hospital stay, lower healthcare costs, and reduced health risks for hospitalized patients. 68Sign up and receive the latest antibiotic news and updates your colleagues and thought leaders are talking about. Paratek, or third parties working on our behalf, will not sell or rent personal health information. In the future, if you no longer want to receive health-related materials or wish to be contacted, please write to Paratek Pharmaceuticals, 75 Park Plaza, 9th Floor, Boston, MA 57666. Please visit http: //paratekpharma. Com/privacy-policy-antibioticriseupcom to view our Privacy Policy. Are you prepared for a data disaster?

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The book closes with My Personal Backup Strategy, and Backup Q&A, where I answer over two dozen of the best and most interesting questions from my survey on backups. You'll find something valuable in each of the 95+ chapters of Everything You Need to Know About BACKUPS. I talk all the time with people who are worried that their computer will crash, or that they'll get a virus or be hacked. Those are signs of Fear and Worry. I've written my ebook Everything You Need to Know About BACKUPS to help you replace those negative thoughts with Knowledge and Confidence. I want you to make this the year when you can say Even if a data disaster happens, I am prepared and I have a plan to recover. Here's the deal. . I'm offering the latest edition of the BACKUPS ebook at a discounted price, with these SPECIAL BONUSES. We take a lot of pride in our rums and beer, which we have become famous for. See where it all started, our local breweries and what you should try when you get here. For the latest news in sport, fashion, hot goss, exclusive specials and great 'vacay' ideas, the Voice of the Island is where you'll find it first. In Jamaica, we’re all about community and working together. There are, however, a couple of Jamaicans who have stood out, and shaped the creative and political Jamaica we live in today. From sculpture to pottery and painting, Jamaica has some of the most talented artists around. Find out what has influenced our art, and how we’re inspired by our island. Sign up to our monthly newsletter to receive the latest news, package deals and promotions. Thanks John a work in progress of course and lots yet to do! Hi Dirk! Greetings TO South Africa! Nice to have you aboard! Well thanks for passing it on but you know you can find a pretty nice acoustic these days for $655 or so. If you decide to pick one up again you know where to find me. Congratulations Jackson!

I am so impressed with your generosity in making this site available to inspire and assist guitar fans everywhere. I am sending a link to my brother, niece and nephew in Alberta who are all heavily involved in the music scene there. I look forward to visiting your site often just to see it evolve even though I am not a guitar player myself. The video is WILD THING Guitar Lesson and can be found on the Three Chord Song page Three Chord Rock. So glad he loves the guitar! Hi Jackson, I really like your lessons and attitude towards life that shows in your personality, you have already taught me more than you can imagine and got me started learning new things again on my guitar. It is easy to get in a rut with practising and new songs are much appreciated. Best regards Rich, live long and propsper, Wow Rich. Thanks for the kind words. I m glad you feel rejuvenated! May the force be with you! Hey Jackson, great site, Have to say you were a big influence on me back in the 85s Mace days. (I spent alot of time at Garys ). You guys opened my ears up to some great music like the Arrows, the Doobie brothers and LRB when I was in my teenage Heavy Metal stage. Those songs stuck with me all my life and made me a better musician. Now I am passing that on to my kids. Thank you! Thanks so much Lee always great to think back to those great days! I hope in some small way the site can help with your family s music! Hope you are still active and above all enjoying it. By the way MACE is still playing. Not sure if you knew. I know what you mean about those gaps Brent. Great to know that you are back at it though and hope I can help a bit with the re-entry!

All the best. JacksonThanks so much Bruce. It s the guitar intro to Layla by Derek and the Dominos. I much appreciate you taking the time to say so. Cheers from Canada! Merci Beaucoup! Hi Jackson, I have been on few sites but find your lessons explain details a lot clearer. I lost my hearing 9 years ago and I loved trying to play guitar. You can understand how devastated I was because I was learning to play guitar at that time, but now I have had a Cochlear implant which gives me hearing back though it s not same as natural hearing. Your videos are very clear and chord and strumming so clear to me and the way you demonstrate above is ace. Merry Christmas. Regards johnMuch appreciated John and I m VERY happy for your improved hearing and health! I just stumbled onto one of your YouTube videos and as a three year guitar player, mainly learning from videos, I think your lessons are the highest quality out there! The video/sound clarity, the rhythm lesson, guitar/amp tone, your attitude, and your voice are all awesome! Great selection of covers to learn. Your website is so professional, that I ll probably sit here all winter. Thank you, thank you, and thank you! Life is good! Well thanks Terry. There are a lot worse things you could be doing so ROCK ON! Well Nic if I ever need an agent I ll be sure to look you up! Thanks so much for the kind words! Hey Jackson, I really enjoy checking out you website. I have been inspried to learn new songs.

I do a local open mic night here in my town and did a song that was really accepted well, Please come to Boston.

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